Mycophenolate Mofetil
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Mycophenolate Mofetil
Mycophenolate Mofetil
Mycophenolate Mofetil (brand name CellCept) is an immunosuppressant medication that can be used to treat autoimmune diseases. It works by preventing certain types of white blood cells, called lymphocytes, from multiplying, which helps to suppress the immune system and prevent it from attacking the body's own tissues. It can be taken as a capsule by mouth.
Side Effects
Common Side Effects
Mycophenolate mofetil can cause various side effects. Contact your healthcare professional if these symptoms become severe .
• Diarrhea
• Nausea and vomiting
• Stomach pain
• Constipation or loose stools
• Headaches
• Fatigue or unusual tiredness
• Heartburn or acid reflux
• Cold sores or open sores in the mouth or on the lips
• Rash
• Acne
• Dizziness
• Trouble sleeping
Serious Side Effects and Risks
Increased Risk of Infection: Mycophenolate mofetil lowers your immune system, increasing the risk of infections, which can be more severe than usual.
Low Blood Cell Counts: This medication can lead to lower white blood cell counts (increasing infection risk), low red blood cell counts (anemia), or low platelet counts.
Malignancy: There is an increased risk of certain cancers, such as skin cancer, and lymphoproliferative disorders with long-term use. Yearly skin examinations and avoiding excessive sun exposure are recommended.
Liver and Kidney Toxicity: While kidney toxicity is rare at typical doses, liver toxicity can occur. Liver dysfunction may require dose adjustments.
Teratogenicity and Pregnancy Loss: Mycophenolate mofetil can harm an unborn baby, causing first-trimester pregnancy loss or serious birth defects.
Important Precautions and Warnings
Pregnancy and Contraception:
• This medication is contraindicated during pregnancy.
• Females of childbearing age must use two methods of highly effective contraception for 4 weeks before starting treatment, during treatment, and for 6 weeks after stopping the medication.
• Males should use reliable contraception during treatment and for at least 90 days after treatment cessation.
• If you become pregnant while taking this medication, inform your care provider immediately.
Drug Interactions
Do not take mycophenolate mofetil at the same time as magnesium antacids or pills, or antacids containing aluminum, as they can affect how your body uses the medication by decreasing absorption.
Vaccinations
Live virus vaccinations are not recommended before or during mycophenolate mofetil treatment.
Monitoring
Regular blood tests are necessary to check kidney, liver, and bone marrow function. These tests may be done every 7-14 days initially, then less frequently over time (typically every 8 weeks once on stable dosing).
Missed Doses/Vomiting
Ask your healthcare provider or transplant coordinator what to do if you miss a dose or vomit after taking the medication.
Medication List
Always carry a list of all your medications and their doses when visiting healthcare providers or pharmacies.
Other Medications/Supplements
Before taking any other medicines, over-the-counter products, herbal supplements, or alternative therapies, consult your transplant doctor or pharmacist [10].
Dosage
A typical initial dose for autoimmune neurological problems is 500 mg twice daily on an empty stomach, if possible. If tolerated after two weeks, the dose may be increased to 1,000 mg twice daily. The maximum dosage is 1500 mg twice daily. Dosage may need to be adapted for kidney or liver impairment. Your healthcare provider will determine the appropriate dosage for your specific condition.
